![]() Of HCV was also performed for comparison purposes. If the source patient was positive for HCV RNA, he or she was further tested for viral load. HCV PCR, anti-HCV Ab, and ALT assays were performed on serum specimens from subjects with a needlestick injury immediately,Īt 2 weeks, and monthly for 12 months post-incident, if the source patient was anti-HCV Ab-positive and the exposed subject In the present study, the polymerase chain reaction (PCR) was used for qualitative and quantitative assays of HCV RNA toĪchieve early detection and effective management of needlestick exposures to HCV infection and to rule out such infections Measurement of HCV RNA level has been reported to be an advantageous method for early detection of HCV infection. By the time an infection is detected by this approach orĪfter acute hepatitis C has developed, the viral load of the exposed person may already be high and intractable for treatment.Įarly detection of HCV infection is especially important since a low viral load is associated with a more favorable response Some patients never develop the anti-HCV Ab. Although the anti-HCV Ab may appear <6 weeks after the onset of symptoms in acute cases, it may not appear for as longĪs 1 year thereafter. Is tested for anti-HCV Ab and elevated serum alanine aminotransferase (ALT) activity at monthly intervals up to 1 year, in Ĭonventionally, after a needlestick incident, if the source patient has tested positive for anti-HCV Ab, the exposed person Of patients in hospitals are positive for anti-HCV Ab. Needlestick injuries are associated with increased risk of acquiring hepatitis C virus infection, since a significant number (HCV Ab) levels as high as 8.8% has been reported in persons with multiple-needlestick injuries. ![]() It is therefore critical to develop an effective strategy to monitor and manage needlestick incidents in health care workers.Īlthough the transmission of HCV infection by needlestick injury may be infrequent, a prevalence of positive anti-HCV antibody Furthermore, there is no vaccine against HCV. (ie, high rates of progression to chronic hepatitis and cirrhosis). Involve intravenous drug abuse, is a matter of great concern because of the potentially grave consequences of the infection HCV infection induced by needlestick incidents that involve health care workers, or by other parenteral exposures that It is also a majorĪgent of sporadic hepatitis in certain parts of the world. Hepatitis C virus (HCV) is the major cause of non-A and non-B hepatitis associated with blood transfusion. Previous Section Next Section Introduction The exposed subjects were negative for HCV RNA throughout the study and possible infections were quickly ruled out. In the other 13 needlestick incidents, the results of PCR tests of ![]() PCR test for HCV RNA were negative following treatment. She never developed acute hepatitisĬ her serum anti-HCV antibody level and alanine aminotransferase (ALT) activity did not become elevated, and results of her Viral load was very low (800 copies/ml) and she responded well to immediate medical treatment. Subjects, a nurse, the result of the PCR test for HCV RNA was positive at 2 wk after the needlestick incident the nurse’s HCV RNA, and the exposed subjects were negative for anti-HCV antibody at the time of the incidents. Fourteen incidents were studied in which the source patients were positive for both the anti-HCV antibody and Of relying on the conventional anti-HCV antibody test to detect HCV infection after needlestick incidents, we used the polymeraseĬhain reaction (PCR) to achieve earlier detection, to manage a patient more effectively, and to exclude possible infection Infection with hepatitis C virus (HCV) is a matter of great concern because of its potentially grave consequences.
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